A dominant negative mutation in a spliceosomal ATPase affects ATP hydrolysis but not binding to the spliceosome.

PRP16 is an RNA-dependent ATPase required for the second catalytic step of splicing in vitro. A dominant suppressor of a branchpoint mutation in Saccharomyces cerevisiae, the prp16-1 allele, contains a Tyr to Asp change in the nucleotide-binding site consensus sequence. We now find that cells harbor...

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Manylion Llyfryddiaeth

Cyhoeddwyd yn:	Mol Cell Biol
Prif Awduron:	Schwer, B, Guthrie, C
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Taylor & Francis 1992
Pynciau:	Research Article
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364619/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1385854/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.12.8.3540-3547.1992
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