Thymidylate synthase protein expression by IHC and gene copy number by SISH correlate and show great variability in non-small cell lung cancer

INTRODUCTION: Increased expression of thymidylate synthase (TS) is thought to be associated with resistance to TS-targeting drugs, e.g. pemetrexed. METHODS: TS protein expression (PE) and gene copy number (GCN) were assayed using immunohistchemistry (IHC) and silver in situ hybridization (SISH), res...

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Main Authors: Wynes, Murry W., Konopa, Krzysztof, Singh, Shalini, Reyna-Asuncion, Bernadette, Ranger-Moore, James, Sternau, Adam, Christoph, Daniel C., Dziadziuszko, Rafal, Jassem, Jacek, Hirsch, Fred R.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3645942/
https://ncbi.nlm.nih.gov/pubmed/22551903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e31824fe95a
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