Frataxin Deficiency Leads to Reduced Expression and Impaired Translocation of NF-E2-Related Factor (Nrf2) in Cultured Motor Neurons

Oxidative stress has been implicated in the pathogenesis of Friedreich’s Ataxia (FRDA), a neurodegenerative disease caused by the decreased expression of frataxin, a mitochondrial protein responsible of iron homeostasis. Under conditions of oxidative stress, the activation of the transcription facto...

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Bibliografiske detaljer
Main Authors: D’Oria, Valentina, Petrini, Stefania, Travaglini, Lorena, Priori, Chiara, Piermarini, Emanuela, Petrillo, Sara, Carletti, Barbara, Bertini, Enrico, Piemonte, Fiorella
Format: Artigo
Sprog:Inglês
Udgivet: Molecular Diversity Preservation International (MDPI) 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3645720/
https://ncbi.nlm.nih.gov/pubmed/23574943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms14047853
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