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Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9

The membrane–cytosol interface is the major locus of control of actin polymerization. At this interface, phosphoinositides act as second messengers to recruit membrane-binding proteins. We show that curved membranes, but not flat ones, can use phosphatidylinositol 3-phosphate [PI(3)P] along with pho...

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Detalhes bibliográficos
Main Authors: Gallop, Jennifer L., Walrant, Astrid, Cantley, Lewis C., Kirschner, Marc W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3645562/
https://ncbi.nlm.nih.gov/pubmed/23589871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305286110
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