FAK-Related Nonkinase Is a Multifunctional Negative Regulator of Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease whose underlying molecular mechanisms are largely unknown. Herein, we show that focal adhesion kinase–related nonkinase (FRNK) plays a key role in limiting the development of lung fibrosis. Loss of FRNK function in vivo leads...

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Detalhes bibliográficos
Main Authors: Ding, Qiang, Cai, Guo-qiang, Hu, Meng, Yang, Youfeng, Zheng, Anni, Tang, Qinjiu, Gladson, Candece L., Hayasaka, Haurko, Wu, Hongju, You, Zhiying, Southern, Brian D., Grove, Lisa M., Rahaman, S. Ohidar, Fang, Haotian, Olman, Mitchell A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2013
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644718/
https://ncbi.nlm.nih.gov/pubmed/23499373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.01.026
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