Microfluidic Screening of Electrophoretic Mobility Shifts Elucidates Riboswitch Binding Function

Riboswitches are RNA sensors that change conformation upon binding small molecule metabolites, in turn modulating gene expression. Our understanding of riboswitch regulatory function would be accelerated by a high throughput, quantitative screening tool capable of measuring riboswitch-ligand binding...

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Bibliografiske detaljer
Main Authors: Karns, Kelly, Vogan, Jacob M., Qin, Qian, Hickey, Scott F., Wilson, Stephen C., Hammond, Ming C., Herr, Amy E.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644558/
https://ncbi.nlm.nih.gov/pubmed/23343213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja310742m
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