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Microfluidic Screening of Electrophoretic Mobility Shifts Elucidates Riboswitch Binding Function
Riboswitches are RNA sensors that change conformation upon binding small molecule metabolites, in turn modulating gene expression. Our understanding of riboswitch regulatory function would be accelerated by a high throughput, quantitative screening tool capable of measuring riboswitch-ligand binding...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3644558/ https://ncbi.nlm.nih.gov/pubmed/23343213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja310742m |
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