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Gain-of-function haplotypes in the vesicular monoamine transporter promoter are protective for Parkinson disease in women

The vesicular monoamine transporter can protect against toxins that induce an acute parkinsonian syndrome. It has been hypothesized that cytoplasmic dopamine has subacute toxic effects in Parkinson Disease (PD) leading to neuronal death and clinical symptoms. Regulatory polymorphisms in the brain fo...

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Detalhes bibliográficos
Main Authors: Glatt, Charles E., Wahner, Angelika D., White, Daniel J., Ruiz-Linares, Andres, Ritz, Beate
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643966/
https://ncbi.nlm.nih.gov/pubmed/16339215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddi445
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