Identification and Characterization of the Direct Interaction between Methotrexate (MTX) and High-Mobility Group Box 1 (HMGB1) Protein

BACKGROUND: Methotrexate (MTX) is an agent used in chemotherapy of tumors and autoimmune disease including rheumatoid arthritis (RA). In addition, MTX has some anti-inflammatory activity. Although dihydrofolate reductase (DHFR) is a well-known target for the anti-tumor effect of MTX, the mode of act...

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Autores principales: Kuroiwa, Yuki, Takakusagi, Yoichi, Kusayanagi, Tomoe, Kuramochi, Kouji, Imai, Takahiko, Hirayama, Tomoko, Ito, Ichiaki, Yoshida, Michiteru, Sakaguchi, Kengo, Sugawara, Fumio
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643934/
https://ncbi.nlm.nih.gov/pubmed/23658798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063073
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