MBNL1 and PTB cooperate to repress splicing of Tpm1 exon 3

Exon 3 of the rat α-tropomyosin (Tpm1) gene is repressed in smooth muscle cells, allowing inclusion of the mutually exclusive partner exon 2. Two key types of elements affect repression of exon 3 splicing: binding sites for polypyrimidine tract-binding protein (PTB) and additional negative regulator...

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Bibliographic Details
Main Authors: Gooding, Clare, Edge, Christopher, Lorenz, Mike, Coelho, Miguel B., Winters, Mikael, Kaminski, Clemens F., Cherny, Dmitry, Eperon, Ian C., Smith, Christopher W.J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
Subjects:
Gene Regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643581/
https://ncbi.nlm.nih.gov/pubmed/23511971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt168
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