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S-nitrosoglutathione reductase deficiency increases mutagenesis from alkylation in mouse liver

In human hepatocellular carcinoma (HCC) and many other cancers, somatic point mutations are highly prevalent, yet the mechanisms critical in their generation remain poorly understood. S-nitrosoglutathione reductase (GSNOR), a key regulator of protein S-nitrosylation, is frequently deficient in human...

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Hlavní autoři: Leung, James, Wei, Wei, Liu, Limin
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643423/
https://ncbi.nlm.nih.gov/pubmed/23354311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgt031
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