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S-nitrosoglutathione reductase deficiency increases mutagenesis from alkylation in mouse liver
In human hepatocellular carcinoma (HCC) and many other cancers, somatic point mutations are highly prevalent, yet the mechanisms critical in their generation remain poorly understood. S-nitrosoglutathione reductase (GSNOR), a key regulator of protein S-nitrosylation, is frequently deficient in human...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3643423/ https://ncbi.nlm.nih.gov/pubmed/23354311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgt031 |
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