Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.

We have constructed a series of point mutations in the highly conserved FLVRES motif of the src homology 2 (SH2) domain of the abl tyrosine kinase. Mutant SH2 domains were expressed in bacteria, and their ability to bind to tyrosine-phosphorylated proteins was examined in vitro. Three mutants were g...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Mayer, B J, Jackson, P K, Van Etten, R A, Baltimore, D
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1992
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC364250/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1370711/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.12.2.609-618.1992
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