Adipocyte pyruvate dehydrogenase kinase 4 expression is associated with augmented PPARγ upregulation in early-life programming of later obesity

We studied adipocytes from 8-week-old control rat offspring (CON) or rat offspring subjected to maternal low (8%) protein (MLP) feeding during pregnancy/lactation, a procedure predisposing to obesity. Acute exposure to isoproterenol or adenosine enhanced PDK4 and PPARγ mRNA gene expression in CON an...

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Main Authors: Holness, Mark J., Zariwala, Gulrez, Walker, Celia G., Sugden, Mary C.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642103/
https://ncbi.nlm.nih.gov/pubmed/23650578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2012.02.003
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