DRAM Triggers Lysosomal Membrane Permeabilization and Cell Death in CD4(+) T Cells Infected with HIV

Productive HIV infection of CD4(+) T cells leads to a caspase-independent cell death pathway associated with lysosomal membrane permeabilization (LMP) and cathepsin release, resulting in mitochondrial outer membrane permeabilization (MOMP). Herein, we demonstrate that HIV infection induces damage-re...

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Main Authors: Laforge, Mireille, Limou, Sophie, Harper, Francis, Casartelli, Nicoletta, Rodrigues, Vasco, Silvestre, Ricardo, Haloui, Houda, Zagury, Jean-Francois, Senik, Anna, Estaquier, Jerome
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642063/
https://ncbi.nlm.nih.gov/pubmed/23658518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003328
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