Recombinant Monovalent Llama-Derived Antibody Fragments (VHH) to Rotavirus VP6 Protect Neonatal Gnotobiotic Piglets against Human Rotavirus-Induced Diarrhea

Group A Rotavirus (RVA) is the leading cause of severe diarrhea in children. The aims of the present study were to determine the neutralizing activity of VP6-specific llama-derived single domain nanoantibodies (VHH nanoAbs) against different RVA strains in vitro and to evaluate the ability of G6P[1]...

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Detalhes bibliográficos
Main Authors: Vega, Celina G., Bok, Marina, Vlasova, Anastasia N., Chattha, Kuldeep S., Gómez-Sebastián, Silvia, Nuñez, Carmen, Alvarado, Carmen, Lasa, Rodrigo, Escribano, José M., Garaicoechea, Lorena L., Fernandez, Fernando, Bok, Karin, Wigdorovitz, Andrés, Saif, Linda J., Parreño, Viviana
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642062/
https://ncbi.nlm.nih.gov/pubmed/23658521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003334
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