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Mycobacterium tuberculosis infected CBA/J mice can generate robust and protective responses to antigen Ag85 when delivered as a soluble protein, but fail to respond efficiently in the context of natural infection
In CBA/J mice, susceptibility to Mycobacterium tuberculosis (M.tb) is associated with low interferon-gamma (IFN-γ) responses to antigens (Antigen 85 (Ag85) and Early Secreted Antigenic Target-6 (ESAT-6)) that have been defined as immunodominant. Here, we asked whether the failure of CBA/J mice to re...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3641789/ https://ncbi.nlm.nih.gov/pubmed/22531914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201142054 |
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