Mycobacterium tuberculosis infected CBA/J mice can generate robust and protective responses to antigen Ag85 when delivered as a soluble protein, but fail to respond efficiently in the context of natural infection

In CBA/J mice, susceptibility to Mycobacterium tuberculosis (M.tb) is associated with low interferon-gamma (IFN-γ) responses to antigens (Antigen 85 (Ag85) and Early Secreted Antigenic Target-6 (ESAT-6)) that have been defined as immunodominant. Here, we asked whether the failure of CBA/J mice to re...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Beamer, Gillian L., Cyktor, Joshua, Flaherty, David K., Stromberg, Paul C., Carruthers, Bridget, Turner, Joanne
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3641789/
https://ncbi.nlm.nih.gov/pubmed/22531914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201142054
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk