MDA5 Plays a Crucial Role in Enterovirus 71 RNA-Mediated IRF3 Activation

Induction of type-I interferons (IFNs), IFN-α/β, is crucial to innate immunity against RNA virus infection. Cytoplasmic retinoic acid-inducible gene I (RIG-I)-like receptors, including RIG-I and melanoma differentiation-associated gene 5 (MDA5), are critical pathogen sensors for activation of type-I...

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Detalhes bibliográficos
Principais autores: Kuo, Rei-Lin, Kao, Li-Ting, Lin, Sue-Jane, Wang, Robert Yung-Liang, Shih, Shin-Ru
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3641126/
https://ncbi.nlm.nih.gov/pubmed/23650567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063431
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