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Genotype to Phenotype Mapping and the Fitness Landscape of the E. coli lac Promoter

Genotype-to-phenotype maps and the related fitness landscapes that include epistatic interactions are difficult to measure because of their high dimensional structure. Here we construct such a map using the recently collected corpora of high-throughput sequence data from the 75 base pairs long mutag...

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Bibliografski detalji
Glavni autori: Otwinowski, Jakub, Nemenman, Ilya
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3641078/
https://ncbi.nlm.nih.gov/pubmed/23650500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061570
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