Targeting the Vav3 oncogene enhances docetaxel-induced apoptosis through the inhibition of androgen receptor phosphorylation in LNCaP prostate cancer cells under chronic hypoxia

BACKGROUND: The Vav family of Rho/Rac guanosine nucleotide exchange factors comprises three members in mammalian cells. Vav3 enhances androgen receptor (AR) activity during progression to androgen independence in prostate cancer. We examined Vav3 small interfering RNA (siRNA) effects on cell prolife...

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Detalhes bibliográficos
Main Authors: Nomura, Takeo, Yamasaki, Mutsushi, Hirai, Kenichi, Inoue, Toru, Sato, Ryuta, Matsuura, Keiko, Moriyama, Masatsugu, Sato, Fuminori, Mimata, Hiromitsu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640915/
https://ncbi.nlm.nih.gov/pubmed/23566222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-27
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