Low frequency genetic variants in the mu-opioid receptor (OPRM1) affect risk for addiction to heroin and cocaine

The μ-opioid receptor (MOR) binds exogenous and endogenous opioids and is known to mediate the rewarding effects of drugs of abuse. Numerous genetic studies have sought to identify common genetic variation in the gene encoding MOR (OPRM1) that affects risk for drug addiction. The purpose of this stu...

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Main Authors: Clarke, Toni-Kim, Crist, Richard C., Kampman, Kyle M., Dackis, Charles A., Pettinati, Helen M., O’Brien, Charles P., Oslin, David W., Ferraro, Thomas N., Lohoff, Falk W., Berrettini, Wade H.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640707/
https://ncbi.nlm.nih.gov/pubmed/23454283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2013.02.018
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