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Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy

Fingolimod is the first oral disease-modifying therapy approved for relapsing forms of multiple sclerosis (MS). Following phosphorylation in vivo, the active agent, fingolimod phosphate (fingolimod-P), acts as a sphingosine 1-phosphate (S1P) receptor modulator, binding with high affinity to four of...

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Main Authors: Groves, Aran, Kihara, Yasuyuki, Chun, Jerold
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640626/
https://ncbi.nlm.nih.gov/pubmed/23518370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jns.2013.02.011
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