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Variation in Heterozygosity Predicts Variation in Human Substitution Rates between Populations, Individuals and Genomic Regions
The “heterozygote instability” (HI) hypothesis suggests that gene conversion events focused on heterozygous sites during meiosis locally increase the mutation rate, but this hypothesis remains largely untested. As humans left Africa they lost variability, which, if HI operates, should have reduced t...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3639965/ https://ncbi.nlm.nih.gov/pubmed/23646173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063048 |
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