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Promoter Polymorphisms in the ATP Binding Cassette Transporter Gene Influence Production of Cell-Derived Microparticles and Are Highly Associated with Susceptibility to Severe Malaria in Humans

Microparticle (MP) efflux is known to be mediated by the ABCA1 protein, and the plasma level of these cell-derived MPs is elevated considerably during human malarial infection. Therefore, two polymorphisms at positions −477 and −320 in the promoter of the ABCA1 gene were genotyped and tested for ass...

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Detalhes bibliográficos
Main Authors: Sahu, Upasana, Mohapatra, Biranchi N., Kar, Shantanu K., Ranjit, Manoranjan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3639614/
https://ncbi.nlm.nih.gov/pubmed/23381994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01175-12
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