Phospholipase C of Cryptococcus neoformans Regulates Homeostasis and Virulence by Providing Inositol Trisphosphate as a Substrate for Arg1 Kinase

Phospholipase C (PLC) of Cryptococcus neoformans (CnPlc1) is crucial for virulence of this fungal pathogen. To investigate the mechanism of CnPlc1-mediated signaling, we established that phosphatidylinositol 4,5-bisphosphate (PIP(2)) is a major CnPlc1 substrate, which is hydrolyzed to produce inosit...

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Autori principali: Lev, Sophie, Desmarini, Desmarini, Li, Cecilia, Chayakulkeeree, Methee, Traven, Ana, Sorrell, Tania C., Djordjevic, Julianne T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
Soggetti:
Molecular Pathogenesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3639591/
https://ncbi.nlm.nih.gov/pubmed/23381992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01421-12
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