Association of Anthracycline-Related Cardiac Histological Lesions With NADPH Oxidase Functional Polymorphisms

OBJECTIVE. Treatment with anthracyclines may cause cardiac dysfunction, but the sequence of anthracycline-induced heart lesions has been incompletely characterized. NADPH oxidase, a key mediator of oxidative cardiac damage and remodeling, modulates anthracycline clinical cardiotoxicity. Our aim was...

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Hlavní autoři: Cascales, Almudena, Pastor-Quirante, Francisco, Sánchez-Vega, Beatriz, Luengo-Gil, Ginés, Corral, Javier, Ortuño-Pacheco, Guzmán, Vicente, Vicente, de la Peña, Francisco Ayala
Médium: Artigo
Jazyk:Inglês
Vydáno: AlphaMed Press 2013
Témata:
New Drug Development and Clinical Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3639532/
https://ncbi.nlm.nih.gov/pubmed/23576480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2012-0239
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