Heparan Sulfate, Including that in Bruch’s Membrane, Inhibits the Complement Alternative Pathway: Implications for Age-related Macular Degeneration

An imbalance between activation and inhibition of the complement system has been implicated in the etiologies of numerous common diseases. Allotypic variants of a key complement fluid phase regulatory protein, complement factor H (CFH), are strongly associated with age-related macular degeneration (...

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Main Authors: Kelly, Una, Yu, Ling, Kumar, Pallavi, Ding, Jin-Dong, Jiang, Haixiang, Hageman, Gregory S., Arshavsky, Vadim Y., Frank, Michael M., Hauser, Michael A., Rickman, Catherine Bowes
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3639479/
https://ncbi.nlm.nih.gov/pubmed/20876352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0903596
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