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SEQUENCE ANALYSIS OF PEPTIDE:OLIGONUCLEOTIDE HETEROCONJUGATES BY ELECTRON CAPTURE DISSOCIATION AND ELECTRON TRANSFER DISSOCIATION

Mass spectrometry analysis of protein-nucleic acid cross-links is challenging due to the dramatically different chemical properties of the two components. Identifying specific sites of attachment between proteins and nucleic acids requires methods that enable sequencing of both the peptide and oligo...

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Detalhes bibliográficos
Main Authors: Krivos, Kady L., Limbach, Patrick A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3638748/
https://ncbi.nlm.nih.gov/pubmed/20435485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jasms.2010.03.043
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