The failure of animal models of neuroprotection in acute ischemic stroke to translate to clinical efficacy

Summary The discrepancy in results regarding neuroprotective agents in animal experiments compared to clinical trials is a major problem. While many neuroprotective agents have been proven effective in a variety of animal ischemic stroke models, none have been shown to work in phase III clinical tri...

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Main Authors: Xu, Sui-yi, Pan, Su-yue
Formato: Artigo
Idioma:Inglês
Publicado em: International Scientific Literature, Inc. 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3638705/
https://ncbi.nlm.nih.gov/pubmed/23353570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSMBR.883750
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https://ncbi.nlm.nih.gov/pmc/articles/PMC3638705/
https://ncbi.nlm.nih.gov/pubmed/23353570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSMBR.883750