Stop Antibiotics on guidance of Procalcitonin Study (SAPS): a randomised prospective multicenter investigator-initiated trial to analyse whether daily measurements of procalcitonin versus a standard-of-care approach can safely shorten antibiotic duration in intensive care unit patients - calculated sample size: 1816 patients

BACKGROUND: Unnecessary long-term use of broad-spectrum antibiotics is linked to the emergence and selection of resistant bacteria, prolonged hospitalisation and increased costs. Several clinical trials indicate that the biomarker procalcitonin (PCT) can guide antibiotic therapy. Some of these trial...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Assink-de Jong, Evelien, de Lange, Dylan W, van Oers, Jos A, Nijsten, Maarten W, Twisk, Jos W, Beishuizen, Albertus
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Study Protocol
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637799/
https://ncbi.nlm.nih.gov/pubmed/23590389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2334-13-178
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