Stop Antibiotics on guidance of Procalcitonin Study (SAPS): a randomised prospective multicenter investigator-initiated trial to analyse whether daily measurements of procalcitonin versus a standard-of-care approach can safely shorten antibiotic duration in intensive care unit patients - calculated sample size: 1816 patients

BACKGROUND: Unnecessary long-term use of broad-spectrum antibiotics is linked to the emergence and selection of resistant bacteria, prolonged hospitalisation and increased costs. Several clinical trials indicate that the biomarker procalcitonin (PCT) can guide antibiotic therapy. Some of these trial...

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Detalhes bibliográficos
Main Authors: Assink-de Jong, Evelien, de Lange, Dylan W, van Oers, Jos A, Nijsten, Maarten W, Twisk, Jos W, Beishuizen, Albertus
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Study Protocol
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637799/
https://ncbi.nlm.nih.gov/pubmed/23590389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2334-13-178
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