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Protein chemical synthesis by serine and threonine ligation

An efficient method has been developed for the salicylaldehyde ester-mediated ligation of unprotected peptides at serine (Ser) or threonine (Thr) residues. The utility of this peptide ligation approach has been demonstrated through the convergent syntheses of two therapeutic peptides––ovine-corticol...

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Autors principals: Zhang, Yinfeng, Xu, Ci, Lam, Hiu Yung, Lee, Chi Lung, Li, Xuechen
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637748/
https://ncbi.nlm.nih.gov/pubmed/23569249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1221012110
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