The Stimulatory Adenosine Receptor ADORA2B Regulates Serotonin (5-HT) Synthesis and Release in Oxygen-Depleted EC Cells in Inflammatory Bowel Disease

OBJECTIVE: We recently demonstrated that hypoxia, a key feature of IBD, increases enterochromaffin (EC) cell 5-HT secretion, which is also physiologically regulated by the ADORA2B mechanoreceptor. Since hypoxia is associated with increased extracellular adenosine, we wanted to examine whether this n...

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Detalhes bibliográficos
Main Authors: Damen, Rikard, Haugen, Martin, Svejda, Bernhard, Alaimo, Daniele, Brenna, Oystein, Pfragner, Roswitha, Gustafsson, Bjorn I., Kidd, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637445/
https://ncbi.nlm.nih.gov/pubmed/23638125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062607
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