Heparanase induced by advanced glycation end products (AGEs) promotes macrophage migration involving RAGE and PI3K/AKT pathway

BACKGROUND: Advanced glycation end products (AGEs), inflammatory-associated macrophage migration and accumulation are crucial for initiation and progression of diabetic vascular complication. Enzymatic activity of heparanase (HPA) is implicated strongly in dissemination of metastatic tumor cells and...

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Detalhes bibliográficos
Main Authors: Qin, Qiaojing, Niu, Jianying, Wang, Zhaoxia, Xu, Wangjie, Qiao, Zhongdong, Gu, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637127/
https://ncbi.nlm.nih.gov/pubmed/23442498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2840-12-37
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