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Computational Investigation of the pH Dependence of Loop Flexibility and Catalytic Function in Glycoside Hydrolases
Cellulase enzymes cleave glycosidic bonds in cellulose to produce cellobiose via either retaining or inverting hydrolysis mechanisms, which are significantly pH-dependent. Many fungal cellulases function optimally at pH ∼5, and their activities decrease dramatically at higher or lower pH. To underst...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3636901/ https://ncbi.nlm.nih.gov/pubmed/23504310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.462465 |
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