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Dual Functions for Cytosolic α-Mannosidase (Man2C1): ITS DOWN-REGULATION CAUSES MITOCHONDRIA-DEPENDENT APOPTOSIS INDEPENDENTLY OF ITS α-MANNOSIDASE ACTIVITY
Cytosolic α-mannosidase (Man2C1) trims free oligosaccharides in mammalian cells, and its down-regulation reportedly delays cancer growth by inducing mitotic arrest or apoptosis. However, the mechanism by which Man2C1 down-regulation induces apoptosis is unknown. Here, we demonstrated that silencing...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3636876/ https://ncbi.nlm.nih.gov/pubmed/23486476 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.425702 |
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