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Genetic instability of modified stem cells - a first step towards malignant transformation?

Induced pluripotent stem cells (iPSC) are important tools in regenerative medicine. Yet, it is becoming increasingly clear that the reprogramming process, including retroviral transduction with potent oncogenes like c-Myc and long-term cultivation, may induce genetic instability. Genetically altered...

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Библиографические подробности
Главные авторы: Steinemann, Doris, Göhring, Gudrun, Schlegelberger, Brigitte
Формат: Artigo
Язык:Inglês
Опубликовано: e-Century Publishing Corporation 2013
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636728/
https://ncbi.nlm.nih.gov/pubmed/23671815
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