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Genetic instability of modified stem cells - a first step towards malignant transformation?

Induced pluripotent stem cells (iPSC) are important tools in regenerative medicine. Yet, it is becoming increasingly clear that the reprogramming process, including retroviral transduction with potent oncogenes like c-Myc and long-term cultivation, may induce genetic instability. Genetically altered...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Steinemann, Doris, Göhring, Gudrun, Schlegelberger, Brigitte
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636728/
https://ncbi.nlm.nih.gov/pubmed/23671815
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