Effect of the Purinergic Inhibitor Oxidized ATP in a Model of Islet Allograft Rejection

The lymphocytic ionotropic purinergic P2X receptors (P2X1R-P2X7R, or P2XRs) sense ATP released during cell damage-activation, thus regulating T-cell activation. We aim to define the role of P2XRs during islet allograft rejection and to establish a novel anti-P2XRs strategy to achieve long-term islet...

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Autors principals: Vergani, Andrea, Fotino, Carmen, D’Addio, Francesca, Tezza, Sara, Podetta, Michele, Gatti, Francesca, Chin, Melissa, Bassi, Roberto, Molano, Ruth D., Corradi, Domenico, Gatti, Rita, Ferrero, Maria E., Secchi, Antonio, Grassi, Fabio, Ricordi, Camillo, Sayegh, Mohamed H., Maffi, Paola, Pileggi, Antonello, Fiorina, Paolo
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2013
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Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636636/
https://ncbi.nlm.nih.gov/pubmed/23315496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0242
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