Phase 2 Study of Pemetrexed and Itraconazole as Second-Line Therapy for Metastatic Non-Squamous Non-Small Cell Lung Cancer

PURPOSE: Preclinical studies suggested that the oral anti-fungal agent itraconazole specifically inhibits proliferation, migration, and tube formation of endothelial cells. Itraconazole has potent anti-angiogenic activity and enhances the efficacy of cytotoxic chemotherapy in multiple primary xenogr...

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Autores principales: Rudin, Charles M., Brahmer, Julie R., Juergens, Rosalyn A., Hann, Christine L., Ettinger, David S., Sebree, Rosa, Smith, Ruth, Aftab, Blake T., Huang, Peng, Liu, Jun O.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636564/
https://ncbi.nlm.nih.gov/pubmed/23546045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e31828c3950
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