Alpha-Synuclein Induces Lysosomal Rupture and Cathepsin Dependent Reactive Oxygen Species Following Endocytosis

α-synuclein dysregulation is a critical aspect of Parkinson's disease pathology. Recent studies have observed that α-synuclein aggregates are cytotoxic to cells in culture and that this toxicity can be spread between cells. However, the molecular mechanisms governing this cytotoxicity and sprea...

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Detalhes bibliográficos
Main Authors: Freeman, David, Cedillos, Rudy, Choyke, Samantha, Lukic, Zana, McGuire, Kathleen, Marvin, Shauna, Burrage, Andrew M., Sudholt, Stacey, Rana, Ajay, O'Connor, Christopher, Wiethoff, Christopher M., Campbell, Edward M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636263/
https://ncbi.nlm.nih.gov/pubmed/23634225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062143
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