Low-dose endotoxin inhalation in healthy volunteers - a challenge model for early clinical drug development

BACKGROUND: Inhalation of endotoxin (LPS) induces a predominantly neutrophilic airway inflammation and has been used as model to test the anti-inflammatory activity of novel drugs. In the past, a dose exceeding 15–50 μg was generally needed to induce a sufficient inflammatory response. For human stu...

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Détails bibliographiques
Auteurs principaux: Janssen, Ole, Schaumann, Frank, Holz, Olaf, Lavae-Mokhtari, Bianca, Welker, Lutz, Winkler, Carla, Biller, Heike, Krug, Norbert, Hohlfeld, Jens M
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635929/
https://ncbi.nlm.nih.gov/pubmed/23537365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2466-13-19
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