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Potentiation of in vitro and in vivo antitumor efficacy of doxorubicin by cyclin-dependent kinase inhibitor P276-00 in human non-small cell lung cancer cells

BACKGROUND: In the present study, we show that the combination of doxorubicin with the cyclin-dependent kinase inhibitor P276-00 was synergistic at suboptimal doses in the non-small cell lung carcinoma (NSCLC) cell lines and induces extensive apoptosis than either drug alone in H-460 human NSCLC cel...

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Библиографические подробности
Главные авторы: Rathos, Maggie J, Khanwalkar, Harshal, Joshi, Kavita, Manohar, Sonal M, Joshi, Kalpana S
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635914/
https://ncbi.nlm.nih.gov/pubmed/23343191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-29
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