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Copy-number variation of cancer-gene orthologs is sufficient to induce cancer-like symptoms in Saccharomyces cerevisiae

BACKGROUND: Copy-number variation (CNV), rather than complete loss of gene function, is increasingly implicated in human disease. Moreover, gene dosage is recognised as important in tumourigenesis, and there is an increasing realisation that CNVs may not be just symptomatic of the cancerous state bu...

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Detalhes bibliográficos
Main Authors: de Clare, Michaela, Oliver, Stephen G
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635878/
https://ncbi.nlm.nih.gov/pubmed/23531409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-11-24
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