MEASURING OF PROTEIN SYNTHESIS USING METABOLIC (2)H-LABELING, HIGH-RESOLUTION MASS SPECTROMETRY AND AN ALGORITHM

We recently developed a method for estimating protin dynamics in vivo with (2)H(2)O using MALDI-TOF MS (Rachdaoui N. et al., MCP, 8, 2653-2662, 2009) and we confirmed that (2)H-labeling of many hepatic free amino acids rapidly equilibrated with body water. Although this is a reliable method, it requ...

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Hlavní autoři: Kasumov, Takhar, Ilchenko, Sergey, Li, Ling, Rachdaoui, Nadia, Sadigov, Rovshan, Willard, Belinda, McCullough, Arthur J., Previs, Stephen
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635850/
https://ncbi.nlm.nih.gov/pubmed/21256107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2011.01.021
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