Neutrophil Mobilization from the Bone Marrow During Polymicrobial Sepsis Is Dependent On CXCL12 Signaling

Neutrophils are essential for successful host eradication of bacterial pathogens and for survival to polymicrobial sepsis. During inflammation, the bone marrow provides a large reserve of neutrophils that are released into the peripheral circulation where they traverse to sites of infection. Althoug...

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Main Authors: Delano, Matthew J., Kelly-Scumpia, Kindra M., Thayer, Terri C., Winfield, Robert D., Scumpia, Philip O., Cuenca, Alex G., Harrington, Phillips B., O’Malley, Kerri A., Warner, Elizabeth, Gabrilovich, Sonia, Mathews, Clayton E., Laface, Drake, Heyworth, Paul G., Ramphal, Reuben, Strieter, Robert M., Moldawer, Lyle L., Efron, Philip A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635667/
https://ncbi.nlm.nih.gov/pubmed/21690321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100588
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