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Constitutive Cdk2 activity promotes aneuploidy while altering the spindle assembly and tetraploidy checkpoints
The cell has many mechanisms for protecting the integrity of its genome. These mechanisms are often weakened or absent in many cancers, leading to high rates of chromosomal instability in tumors. Control of the cell cycle is crucial for the function of these checkpoints, and is frequently lost in ca...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Company of Biologists
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3635462/ https://ncbi.nlm.nih.gov/pubmed/23321641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.117382 |
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