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Qualitative and Quantitative Characterization of the Metabolome, Lipidome and Proteome of Human Hepatocytes Stably Transfected with Cytochrome P450 2E1 Using Data Independent LC-MS
Drug toxicity is a major reason for the failure of candidate pharmaceuticals during their development. It is therefore important to realize the potential for toxicity in a timely fashion. Many xenobiotics are bioactivated into toxic metabolites by cytochromes P450 (CYP). However, the activity of the...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Association of Biomolecular Resource Facilities
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3635362/ |
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