Effect of Malnutrition on the Expression of Cytokines Involved in Th1 Cell Differentiation

Malnutrition is a common cause of secondary immune deficiency and has been linked to an increased susceptibility to infection in humans. Malnutrition specifically affects T-cell-mediated immune responses. The aim of this study was to assess in lymphocytes from malnourished children the expression le...

詳細記述

保存先:
書誌詳細
主要な著者: González-Torres, Cristina, González-Martínez, Haydeé, Miliar, Angel, Nájera, Oralia, Graniel, Jaime, Firo, Verónica, Alvarez, Catalina, Bonilla, Edmundo, Rodríguez, Leonor
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2013
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635214/
https://ncbi.nlm.nih.gov/pubmed/23429441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nu5020579
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!
id pubmed-3635214
record_format dspace
spelling pubmed-36352142013-05-02 Effect of Malnutrition on the Expression of Cytokines Involved in Th1 Cell Differentiation González-Torres, Cristina González-Martínez, Haydeé Miliar, Angel Nájera, Oralia Graniel, Jaime Firo, Verónica Alvarez, Catalina Bonilla, Edmundo Rodríguez, Leonor Nutrients Article Malnutrition is a common cause of secondary immune deficiency and has been linked to an increased susceptibility to infection in humans. Malnutrition specifically affects T-cell-mediated immune responses. The aim of this study was to assess in lymphocytes from malnourished children the expression levels of IL-12, IL-18 and IL-21, molecules that induce the differentiation of T cells related to the immunological cellular response (Th1 response) and the production of cytokines related to the immunological cellular response (Th1 cytokines). We found that the expression levels of IL-12, IL-18 and IL-21 were significantly diminished in malnourished children compared to well-nourished children and were coincident with lower plasmatic levels of IL-2 and IFN-γ (Th1 cytokines). In this study, we show for the first time that the gene expression and intracellular production of cytokines responsible for Th1 cell differentiation (IL-12, IL-18 and IL-21) are diminished in malnourished children. As expected, this finding was related to lower plasmatic levels of IL-2 and IFN-γ. The decreased expression of Th1 cytokines observed in this study may contribute to the deterioration of the immunological Type 1 (cellular) response. We hypothesize that the decreased production of IL-12, IL-18 and IL-21 in malnourished children contributes to their inability to eradicate infections. MDPI 2013-02-19 /pmc/articles/PMC3635214/ /pubmed/23429441 http://dx.doi.org/10.3390/nu5020579 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Article
spellingShingle Article
González-Torres, Cristina
González-Martínez, Haydeé
Miliar, Angel
Nájera, Oralia
Graniel, Jaime
Firo, Verónica
Alvarez, Catalina
Bonilla, Edmundo
Rodríguez, Leonor
Effect of Malnutrition on the Expression of Cytokines Involved in Th1 Cell Differentiation
description Malnutrition is a common cause of secondary immune deficiency and has been linked to an increased susceptibility to infection in humans. Malnutrition specifically affects T-cell-mediated immune responses. The aim of this study was to assess in lymphocytes from malnourished children the expression levels of IL-12, IL-18 and IL-21, molecules that induce the differentiation of T cells related to the immunological cellular response (Th1 response) and the production of cytokines related to the immunological cellular response (Th1 cytokines). We found that the expression levels of IL-12, IL-18 and IL-21 were significantly diminished in malnourished children compared to well-nourished children and were coincident with lower plasmatic levels of IL-2 and IFN-γ (Th1 cytokines). In this study, we show for the first time that the gene expression and intracellular production of cytokines responsible for Th1 cell differentiation (IL-12, IL-18 and IL-21) are diminished in malnourished children. As expected, this finding was related to lower plasmatic levels of IL-2 and IFN-γ. The decreased expression of Th1 cytokines observed in this study may contribute to the deterioration of the immunological Type 1 (cellular) response. We hypothesize that the decreased production of IL-12, IL-18 and IL-21 in malnourished children contributes to their inability to eradicate infections.
author González-Torres, Cristina
González-Martínez, Haydeé
Miliar, Angel
Nájera, Oralia
Graniel, Jaime
Firo, Verónica
Alvarez, Catalina
Bonilla, Edmundo
Rodríguez, Leonor
author_facet González-Torres, Cristina
González-Martínez, Haydeé
Miliar, Angel
Nájera, Oralia
Graniel, Jaime
Firo, Verónica
Alvarez, Catalina
Bonilla, Edmundo
Rodríguez, Leonor
author_sort González-Torres, Cristina
title Effect of Malnutrition on the Expression of Cytokines Involved in Th1 Cell Differentiation
title_short Effect of Malnutrition on the Expression of Cytokines Involved in Th1 Cell Differentiation
title_full Effect of Malnutrition on the Expression of Cytokines Involved in Th1 Cell Differentiation
title_fullStr Effect of Malnutrition on the Expression of Cytokines Involved in Th1 Cell Differentiation
title_full_unstemmed Effect of Malnutrition on the Expression of Cytokines Involved in Th1 Cell Differentiation
title_sort effect of malnutrition on the expression of cytokines involved in th1 cell differentiation
publisher MDPI
publishDate 2013
url https://ncbi.nlm.nih.gov/pmc/articles/PMC3635214/
https://ncbi.nlm.nih.gov/pubmed/23429441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nu5020579
_version_ 1799112474212958208

類似資料