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A Whole Cell Pathway Screen Reveals Seven Novel Chemosensitizers to Combat Chloroquine Resistant Malaria

Due to the widespread prevalence of resistant parasites, chloroquine (CQ) was removed from front-line antimalarial chemotherapy in the 1990s despite its initial promise of disease eradication. Since then, resistance-conferring mutations have been identified in transporters such as the PfCRT, that al...

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Detalhes bibliográficos
Main Authors: Ch'ng, Jun-Hong, Mok, Sachel, Bozdech, Zbynek, Lear, Martin James, Boudhar, Aicha, Russell, Bruce, Nosten, Francois, Tan, Kevin Shyong-Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635055/
https://ncbi.nlm.nih.gov/pubmed/23615863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01734
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