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From shape to cells: mouse models reveal mechanisms altering palate development in Apert syndrome

Apert syndrome is a congenital disorder characterized by severe skull malformations and caused by one of two missense mutations, S252W and P253R, on fibroblast growth factor receptor 2 (FGFR2). The molecular bases underlying differential Apert syndrome phenotypes are still poorly understood and it i...

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Detalhes bibliográficos
Main Authors: Martínez-Abadías, Neus, Holmes, Greg, Pankratz, Talia, Wang, Yingli, Zhou, Xueyan, Jabs, Ethylin Wang, Richtsmeier, Joan T.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Limited 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3634659/
https://ncbi.nlm.nih.gov/pubmed/23519026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.010397
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