Well-Defined Degradable Cationic Polylactide as Nanocarrier for the Delivery of siRNA to Silence Angiogenesis in Prostate Cancer

Well-defined tertiary amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide, and utilized here for the delivery of interleukin-8 (IL-8) siRNA via CPLA-IL-8 siRNA nanoplexes. The CPLAs possess remarkable hydrolyt...

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Autori principali: Chen, Chih-Kuang, Law, Wing-Cheung, Aalinkeel, Ravikumar, Nair, Bindukumar, Kopwitthaya, Atcha, Mahajan, Supriya D., Reynolds, Jessica L., Zou, Jiong, Schwartz, Stanley A., Prasad, Paras N., Cheng, Chong
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3634581/
https://ncbi.nlm.nih.gov/pubmed/23184827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201200094
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