Role of Tachykinin 1 and 4 Gene-Derived Neuropeptides and the Neurokinin 1 Receptor in Adjuvant-Induced Chronic Arthritis of the Mouse

OBJECTIVE: Substance P, encoded by the Tac1 gene, is involved in neurogenic inflammation and hyperalgesia via neurokinin 1 (NK1) receptor activation. Its non-neuronal counterpart, hemokinin-1, which is derived from the Tac4 gene, is also a potent NK1 agonist. Although hemokinin-1 has been described...

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Bibliographic Details
Main Authors: Borbély, Éva, Hajna, Zsófia, Sándor, Katalin, Kereskai, László, Tóth, István, Pintér, Erika, Nagy, Péter, Szolcsányi, János, Quinn, John, Zimmer, Andreas, Stewart, James, Paige, Christopher, Berger, Alexandra, Helyes, Zsuzsanna
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3634005/
https://ncbi.nlm.nih.gov/pubmed/23626716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061684
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